Prevalence of significant liver disease in human immunodeficiency virus-infected patients exposed to Didanosine: A cross sectional study Observational Study

نویسندگان

Sarah Logan

Alison Rodger

Laura Maynard-Smith

James O’Beirne

Thomas Fernandez

Filippo Ferro

Colette Smith

Sanjay Bhagani

چکیده

AIM To identify significant liver disease [including nodular regenerative hyperplasia (NRH)] in asymptomatic Didanosine (DDI) exposed human immunodeficiency virus (HIV) positive patients. METHODS Patients without known liver disease and with > 6 mo previous DDI use had liver stiffness assessed by transient elastography (TE). Those with alanine transaminase (ALT) above upper limit normal and/or TE > 7.65 kPa underwent ultrasound scan (U/S). Patients with: (1) abnormal U/S; or (2) elevated ALT plus TE > 7.65 kPa; Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.4254/wjh.v8.i36.1623 World J Hepatol 2016 December 28; 8(36): 1623-1628 ISSN 1948-5182 (online) © 2016 Baishideng Publishing Group Inc. All rights reserved.

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